PHG Foundation and our partners in the COGS (Collaborative Oncological Gene-environment Study) Consortium have published a significant collection of papers in the current issue of Nature Genetics, which is a special edition focusing on the COGS Consortium's groundbreaking work advancing our understanding of the genetic epidemiology of cancer.

Our commentary in the Nature Genetics special issue is: Public health implications from COGS and potential for risk stratification and screening. What follows is a news release describing that work and outlining its principle findings.
 

Personalised cancer screening to include genetic testing
Future cancer screening may be improved by the use of genetic information, predicts new research led by the PHG Foundation and the University of Cambridge; but greater accuracy will come at the price of increased complexity.

The research is part of a major international scientific collaborative study into the genetic risk of breast, ovarian and prostate cancer, known as the Collaborative Oncological Gene-environment Study (COGS). The PHG Foundation led work on the implications that the study’s research results have for the people working in health services and the people who use those services.

Principal investigator Dr Hilary Burton, Director of the PHG Foundation, said: “For the last decade scientists have envisaged a future where Genome Wide Association Studies (GWAS) would lead to stratification of populations and improved prevention based on genetic susceptibility.  This is the first time one of these major international studies has been associated with a parallel process using real results to investigate the potential impact on population health. Our conclusion is stratified prevention is possible and useful, but is complex. To achieve this vision of the future effective engagement between policy-makers, the public and the researchers is crucial”.

How cancer screening will change
The overall research from COGS found that testing for genetic variants that increase the risk of breast and prostate cancer risk could be used to refine screening programmes by stratifying populations, ultimately helping to target disease prevention and reducing harm.

Screening aims to detect cancer at an early stage, maximising successful treatment. Current programmes, such as the NHS Breast Screening Programme, offer a standard package of screening over an agreed age range where the risk of disease is typically greatest; the addition of genetic information will help identify those who may benefit most from screening.  Stratification could lead to fewer people needing to be screened;  better detection of more aggressive cancers in younger age groups , and the number of ‘false-positive’ results (where no cancer is present) to fall.

The report authors, all researchers from the PHG Foundation and the Cambridge Institute of Public Health (CIPH), conclude that genetic research can be used to create new and improved stratified screening programmes.  However, they warn that stratified screening will be complex, requiring genetic testing and integration of results into a risk assessment process as well as differential care pathways for people in different risk groups. Questions about the storage, access and privacy of genetic data will also arise.  In addition, the greater complexity of such screening makes it essential that relevant health professionals develop their understanding of genetics.

See our full press release for further details, notes and contact information (PDF).

Read the full commentary in the current issue of Nature Genetics.

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