Pink, parkin and the brain. Pallanck L and Greenamyre JT (2006) Nature 441, 1058. News and views piece on mutations in the PINK1 gene and their role in Parkinson’s disease (PubMed).
Mitochondrial disease. Schiapira AHV (2006) Lancet 368, 70-82. Review of recent advances in the understanding of diseases associated with mitochondrial defects, including genotype-phenotype correlations, inheritance and penetrance, and prospects for accurate genetic counselling and the development of novel therapies.
Statistical false positive or true disease pathway? Todd JA (2006) Nat Genet. 38(7), 731-733. Commentary on how new collaborative approaches combined with well-designed epidemiological studies may at last be yielding genuine disease-gene associations (PubMed).
CIMPle origin for promoter hypermethylation in colorectal cancer? Schuebel K, Chen W and Baylin SB (2006) Nat Genet. 38(7), 738-40. News and views article on the role of promoter CpG island DNA methylation in colorectal cancer (PubMed).
GATA1s goes germline. Mundschau G and Crispino J (2006) Nat Genet. 38(7), 741-2. News and views article on a recent study showing that inherited GATA1 mutations cause defects in multiple hematopoietic cell lines (PubMed).
If it's not one thing, it's another. Paulson HL (2006) Nat Genet. 38(7), 743-4. News and views article on new evidence that spinocerebellar ataxia type 8 may be caused via two distinct molecular mechanisms arising from transcription in opposite directions from a CTG/CAG repeat expansion (PubMed).