RNA interference as potential therapy - not so fast. Marsden PA (2006) N Engl J Med. 355, 953-4. Commentary on the clinical implications of current research into RNAi as a therapeutic intervention (PubMed).
Reconstructing human origins in the genomic era. Garrigan D and Hammer MF (2006) Nat Rev Genet. 7, 669-80. Review of genetic and statistical methods for analysis of the evolution of human populations (PubMed).
Insulators: exploiting transcriptional and epigenetic mechanisms. Gaszner M and Felsenfeld G (2006) Nat Rev Genet. 7, 703-13. Review of DNA insulators, sequence elements that separate regions of chromatin (PubMed).
Public health and human values. Hayry M (2006) J Med Ethics 32, 519-21. Ethical discussion on whether the aims of public health are at odds with the values of individuals and communities (PubMed).
Chromosome instability leaves its mark. Pollack JR (2006) Nat Genet. 38, 973-4. News and views article on genomic instability as a hallmark of cancer, accompanying the report of a new gene expression signature of aneuploidy with clinical predictive value (PubMed).
Genome structural variation and sporadic disease traits. Lupski JR (2006) Nat Genet. 38, 974-6. News and views piece on how genomic rearrangements can lead to sporadic disease, and prospects for identification of the genetic causes of certain disease traits (PubMed).
Reversal of fortune. Timchenko L (2006) Nat Genet. 38, 976-7. News and views articles on how reducing the numbers of CUG-repeat transcripts reverses symptoms in a mouse model of myotonic dystrophy (PubMed).