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The Human Genome Epidemiology Network (HuGENet™), which is an international collaborative venture to investigate the role of human genome variation in population health, has launched a new resource for genome epidemiologists (see HuGE news). HuGE Navigator is a searchable and continuously updated knowledge base of human gene-disease associations; it also includes information on gene-gene and gene- environment interactions, population prevalence of genetic variants, and the evaluation of genetic tests. The new HuGE Navigator replaces older database search tools as well as offering additional functions for researchers.