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New epigenetic map resource in development

Report of a story in the news   |   By Dr Philippa Brice   |   Published 13 June 2011

Sources: Epigenomics Program, Roadmap Epigenomics Project

A new resource of epigenetic maps is in development for use by researchers. 

The Reference Epigenome Mapping Consortium, part of the Roadmap Epigenomics Program funded by the US NIH, are creating a ‘community resource’ of genome-wide epigenetic maps from different human cell types.  More than a hundred samples from adult and fetal cells, including stem cells, are being mapped for core epigenetic features including histone modifications, DNA methylation and chromatin accessibility, along with gene expression data connected with these features. 

Epigenetic maps already completed of human embryonic stem (HES) cells and induced pluripotent stem (iPS) cells have reportedly shown significant differences, with potential implications for the development of stem cell therapeutics - although other work reported earlier this year that epigenetic and transcriptional profiles had revealed high levels of equivalence between HES and iPS cells (see previous news). 

Keywords: Epigenetics, Stem Cells

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