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Demonstrate that quick de novo DNA sequencing is possible using low-cost semiconductor  technology.

Developed a system for electronic DNA sequencing based on monitoring changes in voltage as nucleotides are incorporated into a DNA strand. This was based on making improvements to the design of ion chips on which the sequencing reaction takes place, the supporting instrumentation and software. The performance of the system was tested by sequencing three bacterial genomes and producing a draft genome sequence of Gordon Moore, who is the co-founder of Intel and author of Moore’s Law.

An integrated circuit able to sequence DNA was produced. Three different bacterial genomes were sequenced and comparison with the reference sequence demonstrated a high accuracy. The system was also able to produce a draft human whole genome sequence.

This study demonstrates it is possible  to produce ion chips which will facilitate low-cost routine human genome sequencing.

Although this technology holds promise for low cost sequencing, as stated in the accompanying commentary, wide-spread use will require demonstration of its accuracy. The ability to quickly and accurately sequence genomes is already having a big impact on science (see previous news) and medicine (see previous news). The PHG Foundation is involved in a project looking at the impact of new sequencing technologies for health.