New genetic study of Alzheimer Disease

31 October 2007

Funded by the Wellcome Trust, UK and US researchers are to conduct what is said to be the largest genome-wide association (GWA) study to date for Alzheimer Disease (AD), looking at DNA samples from a total of 14,000 people; 6,000 ‘cases’ with late-onset AD and 8,000 healthy ‘controls’. Project lead Professor Julie Williams of Cardiff University commented: "Alzheimer's is a genetically-complicated story involving many genes, so we need large sample sizes to make sure any genetic links that we find are not mere coincidence… We need to build a complete picture of the different pathways that lead to the disease" (see press release).

The Alzheimer’s Society estimates that number of people in the UK with dementia will exceed one million by 2025; AD is the most common form of dementia (see Facts about dementia).

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