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		<title>Articles from the PHG Foundation Newsletter</title>
		<link>http://www.phgfoundation.org/newsletter</link>
		<description>Articles from the PHG Foundation Newsletter</description>
		<copyright>PHG Foundation</copyright>
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			<title>Reduced prostate cancer survival in BRCA2 mutation carriers</title>
			<link>http://www.phgfoundation.org/news/month/06/2008/#story_4257</link>
			<pubDate>Fri, 27 Jun 2008 00:00:00 +0100</pubDate>
			<description><![CDATA[ A paper in the British Journal of Cancer presents evidence that male carriers of mutations in the BRCA1 or BRCA2 genes (associated with hereditary breast-ovarian cancer syndrome) are not only at five-fold increased risk of prostate cancer compared with the general male population, but also show much ... ]]></description>
		</item>
				<item>
			<title>Complexity in breast cancer susceptibility</title>
			<link>http://www.phgfoundation.org/news/month/11/2007/#story_3902</link>
			<pubDate>Mon, 19 Nov 2007 00:00:00 +0000</pubDate>
			<description><![CDATA[ In this year alone, at least five studies of genome-wide association studies of breast cancer genetics have been published uncovering numerous risk genes involved and highlighting the complexity of genetic susceptibility to multifactorial diseases such as cancer. A recent paper in Clinical Genetics  ... ]]></description>
		</item>
				<item>
			<title>Criticism of breast cancer genetic test advertisement</title>
			<link>http://www.phgfoundation.org/news/month/09/2007/#story_3669</link>
			<pubDate>Wed, 12 Sep 2007 00:00:00 +0100</pubDate>
			<description><![CDATA[ A US television advertisement for familial breast cancer testing has attracted criticism from oncologists and geneticists, who say that advertising a specialised genetic test to the general population could cause anxiety among women for whom the test is not actually appropriate. Director of cancer g ... ]]></description>
		</item>
				<item>
			<title>Parental disclosure of hereditary breast cancer information</title>
			<link>http://www.phgfoundation.org/news/month/08/2007/#story_3626</link>
			<pubDate>Tue, 21 Aug 2007 00:00:00 +0100</pubDate>
			<description><![CDATA[ A paper published in the Journal of Clinical Oncology reports the findings of a US study looking at disclosure of BRCA mutation status (and hence information on familial risk) by parents to children under the age of 25. Carrier status for BRCA mutations in women carries a lifetime risk of up to 85%  ... ]]></description>
		</item>
				<item>
			<title>Limitations of BRCA mutation prediction models for women with early onset breast cancer and no family history</title>
			<link>http://www.phgfoundation.org/news/month/06/2007/#story_3483</link>
			<pubDate>Sat, 30 Jun 2007 00:00:00 +0100</pubDate>
			<description><![CDATA[ Women with breast cancer who carry a mutation in either the BRCA1 or the BRCA2 gene have a substantial risk of a developing a second primary breast tumour or ovarian cancer in the absence of prophylactic intervention such as mastectomy, oophorectomy or tamoxifen treatment. Risk prediction models to  ... ]]></description>
		</item>
				<item>
			<title>Embryo screening for hereditary breast cancer</title>
			<link>http://www.phgfoundation.org/news/month/04/2007/#story_3294</link>
			<pubDate>Mon, 30 Apr 2007 00:00:00 +0100</pubDate>
			<description><![CDATA[ A doctor from University College Hospital, London has submitted an application to the Human Fertilisation and Embryology Authority (HFEA) for permission to perform prenatal genetic diagnosis (PGD) on embryos for the purpose of identifying mutations in the BRCA1 gene associated with hereditary breast ... ]]></description>
		</item>
				<item>
			<title>Genetics and Insurance Committee publish their 5th Annual report</title>
			<link>http://www.phgfoundation.org/news/month/04/2007/#story_3290</link>
			<pubDate>Wed, 25 Apr 2007 00:00:00 +0100</pubDate>
			<description><![CDATA[ The Genetics and Insurance Committee, the non-statutory advisory body with a remit to scrutinise how genetic tests are used and evaluated by the insurance industry, published their 5th annual report on 23rd April 2007. As the report acknowledged, &amp;lsquo;2006 has proven to be a relatively quiet year  ... ]]></description>
		</item>
				<item>
			<title>Genetic testing for familial cancer in the US underutilised</title>
			<link>http://www.phgfoundation.org/news/month/03/2007/#story_3177</link>
			<pubDate>Sat, 10 Mar 2007 00:00:00 +0000</pubDate>
			<description><![CDATA[ A study presented at a US Society of Gynecologic Oncologists (SGO) conference has reported that many American women at high risk of developing familial cancer syndromes such as familial breast-ovarian cancer and hereditary non-polyposis colorectal cancer (HNPCC) were unaware of their elevated risk,  ... ]]></description>
		</item>
				<item>
			<title>UK Clinical Molecular Genetics Society annual audit</title>
			<link>http://www.phgfoundation.org/news/month/02/2007/#story_3113</link>
			<pubDate>Thu, 08 Feb 2007 00:00:00 +0000</pubDate>
			<description><![CDATA[ The annual audit of activity in UK National Health Service genetics laboratories for the year 2005-6 has been completed by the Clinical Molecular Genetics Society (CMGS). A total of more than 78600 postnatal tests were carried out, excluding those for leukaemia and DNA storage (banking); this repres ... ]]></description>
		</item>
				<item>
			<title>Increased risk of breast cancer without BRCA1/2 mutations</title>
			<link>http://www.phgfoundation.org/news/month/11/2006/#story_2776</link>
			<pubDate>Thu, 02 Nov 2006 00:00:00 +0000</pubDate>
			<description><![CDATA[ Inherited mutations in the BRCA1 and BRCA2 genes are associated with strong predisposition to breast and ovarian cancer; lifetime risk is around 85% for mutation carriers. Women at high risk of the disease based on their family history require high levels of surveillance to identify tumours in the e ... ]]></description>
		</item>
				<item>
			<title>Genomic tests for ovarian cancer</title>
			<link>http://www.phgfoundation.org/news/month/10/2006/#story_2759</link>
			<pubDate>Mon, 30 Oct 2006 00:00:00 +0000</pubDate>
			<description><![CDATA[ A new report, Genomic Tests for Ovarian Cancer Detection &amp; Management, has been released by the US Agency for Healthcare Research &amp; Quality (AHRQ). Produced in collaboration with the CDC Division of Cancer Control and Prevention and the National Office of Public Health Genomics, the report considers ... ]]></description>
		</item>
				<item>
			<title>BRCA1/2 mutation testing and risk perception</title>
			<link>http://www.phgfoundation.org/news/month/09/2006/#story_2657</link>
			<pubDate>Mon, 25 Sep 2006 00:00:00 +0100</pubDate>
			<description><![CDATA[ A new paper in the American Journal of Medical Genetics reports the results of an investigation into how BRCA1/2 genetic testing alters the perception of breast and ovarian cancer risk in high-risk families [McInerney-Leo A et al. (2006) Am J Med Genet A. 140A, 2198-2206]. Individuals with a strong  ... ]]></description>
		</item>
				<item>
			<title>BRCA test backlog leads some women to opt for breast removal</title>
			<link>http://www.phgfoundation.org/news/month/06/2006/#story_2524</link>
			<pubDate>Tue, 20 Jun 2006 00:00:00 +0100</pubDate>
			<description><![CDATA[ The charity Breakthrough Breast Cancer has released a warning that delays for genetic test results are so long that women at risk of familial breast cancer are opting for mastectomies rather than wait two years for test results (see news). Familial breast cancer represents up to 5% of all cases; wom ... ]]></description>
		</item>
				<item>
			<title>HFEA announces policy position on PGD for late-onset hereditary conditions that are not completely penetrant</title>
			<link>http://www.phgfoundation.org/news/month/05/2006/#story_2493</link>
			<pubDate>Tue, 09 May 2006 00:00:00 +0100</pubDate>
			<description><![CDATA[ The Human Fertilisation and Embryology Authority (HFEA) has issued draft recommendations on widening the number of conditions for which PGD may be used, for discussion at a public meeting of the authority in Belfast tomorrow (10th May). This follows on from a public consultation on widening the scop ... ]]></description>
		</item>
				<item>
			<title>Familial breast cancer surveillance -  NICE update</title>
			<link>http://www.phgfoundation.org/news/month/05/2006/#story_2507</link>
			<pubDate>Wed, 24 May 2006 00:00:00 +0100</pubDate>
			<description><![CDATA[ The National Institute for Health and Clinical Excellence (NICE) has issued a draft partial update of the clinical practice guideline on Familial breast cancer (CG14), in development for use in the NHS in England and Wales. This is an update to the guidance issued in 2004, and stipulates when MRI (m ... ]]></description>
		</item>
				<item>
			<title>HFEA confirms PGD for hereditary cancers</title>
			<link>http://www.phgfoundation.org/news/month/05/2006/#story_2505</link>
			<pubDate>Tue, 23 May 2006 00:00:00 +0100</pubDate>
			<description><![CDATA[ The Human Fertilisation and Embryology Authority (HFEA) has confirmed its decision to permit pre-implantation genetic diagnosis (PGD) for the selection of embryos free from mutations associated with inherited predisposition to breast, ovarian and bowel cancers (see previous news story).  This decisi ... ]]></description>
		</item>
				<item>
			<title>Familial breast cancer BRCA trial</title>
			<link>http://www.phgfoundation.org/news/month/05/2006/#story_2483</link>
			<pubDate>Tue, 02 May 2006 00:00:00 +0100</pubDate>
			<description><![CDATA[ A new international phase II clinical trial led by Breakthrough Breast Cancer and Cancer Research UK is to look at the effect of a novel form of drug treatment for metastatic hereditary breast cancer. More than three-quarters of all cases of familial breast cancer occur in individuals with mutations ... ]]></description>
		</item>
				<item>
			<title>UK Clinical Molecular Genetics Society annual audit: rise in predictive testing</title>
			<link>http://www.phgfoundation.org/news/month/02/2006/#story_2293</link>
			<pubDate>Mon, 20 Feb 2006 00:00:00 +0000</pubDate>
			<description><![CDATA[ Results from the most recent Clinical Molecular Genetics Society (CMGS) annual audit of activity in UK National Health Service laboratories are now available. The 2004-5 report records a very similar number of postnatal tests as last year (63,500 as opposed to 65,000 for 2003-4); this excludes the f ... ]]></description>
		</item>
				<item>
			<title>Breast cancer genetic test backlog</title>
			<link>http://www.phgfoundation.org/news/month/12/2005/#story_2208</link>
			<pubDate>Wed, 14 Dec 2005 00:00:00 +0000</pubDate>
			<description><![CDATA[     The charity CancerBACUP    has conducted a survey of BRCA1/2 genetic testing in 23 regional genetics centres,    to detect mutations associated with substantially increased risk of breast and    ovarian cancer (see BBC    news item). They report that in two of the 19 centres that responded, wome ... ]]></description>
		</item>
				<item>
			<title>Genomics and Population Health 2005 report</title>
			<link>http://www.phgfoundation.org/news/month/11/2005/#story_2120</link>
			<pubDate>Mon, 07 Nov 2005 00:00:00 +0000</pubDate>
			<description><![CDATA[     The Office of Genomics    and Disease Prevention, part of the US Centers    for Disease Control and Prevention (CDC), has released a new report, Genomics    and Population Health 2005. This follows a previous report    in 2003, and is intended to be of value for “advancing the integration    of  ... ]]></description>
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