<?xml version="1.0" encoding="iso-8859-1"?>
	<!-- 
		XML Comment inserted to enable XSL in Firefox 2.0 
		XML Comment inserted to enable XSL in Firefox 2.0 
		XML Comment inserted to enable XSL in Firefox 2.0 
		XML Comment inserted to enable XSL in Firefox 2.0 
		XML Comment inserted to enable XSL in Firefox 2.0 
		XML Comment inserted to enable XSL in Firefox 2.0 
		XML Comment inserted to enable XSL in Firefox 2.0 
		XML Comment inserted to enable XSL in Firefox 2.0 
		XML Comment inserted to enable XSL in Firefox 2.0 
		XML Comment inserted to enable XSL in Firefox 2.0 
	-->
	<?xml-stylesheet type="text/xsl" href="http://www.phgfoundation.org/public/templates/foundation_corp/xsl/newsletter.xsl"?>
	<rss version="2.0">
		<channel>
		<title>Articles from the PHG Foundation Newsletter</title>
		<link>http://www.phgfoundation.org/newsletter</link>
		<description>Articles from the PHG Foundation Newsletter</description>
		<copyright>PHG Foundation</copyright>
		<list_type>news</list_type>
		<customJS>http://www.phgfoundation.org/rss/newsletter.xml?format=js</customJS>
		
				<item>
			<title>Should oversight of US gene therapy trials change?</title>
			<link>http://www.phgfoundation.org/news/month/03/2012/#story_11466</link>
			<pubDate>Mon, 19 Mar 2012 00:00:00 +0000</pubDate>
			<description><![CDATA[ As the number of gene therapy trials continues to expand, with more than 1150 separate trials in progress in the US alone, American gene therapy experts have said it is time to moderate regulatory oversight.  &amp;nbsp;  Currently, gene therapy clinical trials in the US require review by the federal Rec ... ]]></description>
		</item>
				<item>
			<title>Latest gene therapy result unveiled on Rare Disease Day</title>
			<link>http://www.phgfoundation.org/news/month/02/2012/#story_11357</link>
			<pubDate>Wed, 29 Feb 2012 00:00:00 +0000</pubDate>
			<description><![CDATA[ Gene therapy has shown some benefit against a new rare disease target, chronic granulomatous disorder (CGD), which prevents normal immune responses against bacterial and fungal infections.  &amp;nbsp;  Great Ormond Street Hospital in London has reported that a teenager with CGD has shown a good response ... ]]></description>
		</item>
				<item>
			<title>Gene therapy restores vision in blind patients</title>
			<link>http://www.phgfoundation.org/news/month/02/2012/#story_11258</link>
			<pubDate>Thu, 16 Feb 2012 00:00:00 +0000</pubDate>
			<description><![CDATA[ Though these are very early stage results in just a few patients, they are highly encouraging, especially following on from similar promise shown by gene therapy for another rare genetic eye disorder, Choroideraemia (see previous news). ]]></description>
		</item>
				<item>
			<title>RNA interference and stem cells combat Huntington's disease</title>
			<link>http://www.phgfoundation.org/news/month/02/2012/#story_11219</link>
			<pubDate>Fri, 10 Feb 2012 00:00:00 +0000</pubDate>
			<description><![CDATA[ US researchers have developed an innovative technique that uses stem cells to deliver an RNA interference (RNAi) based therapeutic for Huntington&amp;rsquo;s disease.  &amp;nbsp;  Huntington&amp;rsquo;s disease (HD) is an inherited form of adult-onset, severe progressive neurological condition that results in d ... ]]></description>
		</item>
				<item>
			<title>Gene therapy gains momentum</title>
			<link>http://www.phgfoundation.org/news/month/02/2012/#story_11189</link>
			<pubDate>Mon, 06 Feb 2012 00:00:00 +0000</pubDate>
			<description><![CDATA[ In spite of positive results yielded from dozens of gene therapy trials, to date neither Europe nor the US has given the go ahead for routine use of a single form of gene therapy in the clinic.  &amp;nbsp;  All this may be about to change as calls, and actions, to give patients &amp;ldquo;the treatments the ... ]]></description>
		</item>
				<item>
			<title>Early gene therapy trials for haemophilia B show promise</title>
			<link>http://www.phgfoundation.org/news/month/12/2011/#story_10838</link>
			<pubDate>Tue, 20 Dec 2011 00:00:00 +0000</pubDate>
			<description><![CDATA[ Preliminary results from a trial of viral-based gene therapy for haemophilia have shown that four of the six patients treated were able to stop taking clotting treatments.  &amp;nbsp;  Haemophilia B is a rare disease where inherited mutations prevent the production of a crucial component of the blood cl ... ]]></description>
		</item>
				<item>
			<title>Gene cure in sight for eye disorders</title>
			<link>http://www.phgfoundation.org/news/month/11/2011/#story_10435</link>
			<pubDate>Thu, 03 Nov 2011 00:00:00 +0000</pubDate>
			<description><![CDATA[ &amp;nbsp;A new gene therapy technique is showing promise as a treatment for the rare genetic disorder, Choroideraemia.The disease is caused by an inherited faulty REP1 gene. Without a functioning copy of the gene, the eye&amp;rsquo;s light detecting cells die off. Often diagnosed in childhood, most suffere ... ]]></description>
		</item>
				<item>
			<title>Combined stem cell and gene therapy for liver disease</title>
			<link>http://www.phgfoundation.org/news/month/10/2011/#story_10259</link>
			<pubDate>Thu, 13 Oct 2011 00:00:00 +0100</pubDate>
			<description><![CDATA[ In pioneering work published today, researchers have combined gene therapy with stem cell therapy to correct a genetic liver defect.  &amp;nbsp;  Writing in Nature, the research team reports work to combat the genetic disorder alpha-1 antitrypsin deficiency (A1ATD), which is caused by a mutation in the  ... ]]></description>
		</item>
				<item>
			<title>Successful gene therapy for severe immune deficiency</title>
			<link>http://www.phgfoundation.org/news/month/08/2011/#story_9654</link>
			<pubDate>Fri, 26 Aug 2011 00:00:00 +0100</pubDate>
			<description><![CDATA[  ]]></description>
		</item>
				<item>
			<title>UK strategy for regenerative and cellular medicine unveiled</title>
			<link>http://www.phgfoundation.org/news/month/07/2011/#story_9329</link>
			<pubDate>Fri, 29 Jul 2011 00:00:00 +0100</pubDate>
			<description><![CDATA[ A new government report has set out the challenges for regenerative medicine in the UK and a strategy for future development.  Published by the Office for Life Sciences and the Department of Health (DH), the new report provides an overview of the UK&amp;rsquo;s strengths and weaknesses in regenerative m ... ]]></description>
		</item>
				<item>
			<title>Genome editing corrects haemophilia in mice</title>
			<link>http://www.phgfoundation.org/news/month/07/2011/#story_8944</link>
			<pubDate>Fri, 01 Jul 2011 00:00:00 +0100</pubDate>
			<description><![CDATA[  ]]></description>
		</item>
				<item>
			<title>Novel form of RNA editing suppresses nonsense mutations</title>
			<link>http://www.phgfoundation.org/news/month/06/2011/#story_8826</link>
			<pubDate>Sat, 18 Jun 2011 00:00:00 +0100</pubDate>
			<description><![CDATA[  ]]></description>
		</item>
				<item>
			<title>Gene therapy progress for Parkinson's disease</title>
			<link>http://www.phgfoundation.org/news/month/06/2011/#story_8694</link>
			<pubDate>Fri, 03 Jun 2011 00:00:00 +0100</pubDate>
			<description><![CDATA[ Gene therapies no longer excite media interest in the way they once did; there was perhaps a general disappointment that effective delivery and sustained expression of therapeutic genes proved to be a lot more difficult than originally envisaged. However, applications for a range of relatively commo ... ]]></description>
		</item>
				<item>
			<title>Human cells 'hacked' with programmable circuits</title>
			<link>http://www.phgfoundation.org/news/month/12/2010/#story_6803</link>
			<pubDate>Mon, 06 Dec 2010 00:00:00 +0000</pubDate>
			<description><![CDATA[ Researchers have constructed genetic &amp;lsquo;control circuits&amp;rsquo; that can be programmed to make human cells alter their behaviour in a variety of ways in response to any chosen protein signal. The circuits are RNA sequences consisting of an input component (known as an aptamer) which senses and b ... ]]></description>
		</item>
				<item>
			<title>Possible gene therapy for depression</title>
			<link>http://www.phgfoundation.org/news/month/10/2010/#story_6139</link>
			<pubDate>Wed, 27 Oct 2010 00:00:00 +0100</pubDate>
			<description><![CDATA[  ]]></description>
		</item>
				<item>
			<title>Successful gene therapy for beta-thalassaemia</title>
			<link>http://www.phgfoundation.org/news/month/09/2010/#story_5692</link>
			<pubDate>Thu, 23 Sep 2010 00:00:00 +0100</pubDate>
			<description><![CDATA[ Beta-thalassaemia is a serious genetic disease and particularly common among populations of Mediterranean, Middle Eastern and Asian descent. There is therefore a considerable driving force behind efforts to develop effective gene therapy, and various approaches have been taken (see previous news).   ... ]]></description>
		</item>
				<item>
			<title>Regenerative medicine and spinal cord injuries</title>
			<link>http://www.phgfoundation.org/news/month/08/2010/#story_5635</link>
			<pubDate>Mon, 09 Aug 2010 00:00:00 +0100</pubDate>
			<description><![CDATA[ The Technology Strategy Board, a UK governmental body responsible for driving technological innovation, has announced a total of &amp;pound;5 million funding to support feasibility research and product development for new regenerative medicine &amp;lsquo;products, tools and technologies&amp;rsquo; (see press re ... ]]></description>
		</item>
				<item>
			<title>Long term efficacy of gene therapy for X-linked SCID</title>
			<link>http://www.phgfoundation.org/news/month/07/2010/#story_5589</link>
			<pubDate>Mon, 26 Jul 2010 00:00:00 +0100</pubDate>
			<description><![CDATA[ Gene therapy is the delivery of genetic material to correct a genetic defect associated with severe disease, replacing a non-functional gene with a functional version or inactivating a malfunctioning gene. It is in a sense the &amp;lsquo;holy grail&amp;rsquo; of genetic medicine, offering the potential of a ... ]]></description>
		</item>
				<item>
			<title>Progress in gene therapy for beta-thalassaemia</title>
			<link>http://www.phgfoundation.org/news/month/07/2010/#story_5587</link>
			<pubDate>Thu, 22 Jul 2010 00:00:00 +0100</pubDate>
			<description><![CDATA[ Beta thalassaemia is one of the most common autosomal recessive disorders worldwide and mainly affects individuals from Mediterranean, Middle Eastern and Asian populations. It is caused by mutations in the haemoglobin beta gene leading to either a reduction in &amp;beta;-globin production or the absence ... ]]></description>
		</item>
				<item>
			<title>Use of nanoparticles for cancer therapy and diagnosis</title>
			<link>http://www.phgfoundation.org/news/month/03/2010/#story_5316</link>
			<pubDate>Fri, 26 Mar 2010 00:00:00 +0000</pubDate>
			<description><![CDATA[ RNA interference (RNAi) is a naturally occurring gene silencing mechanism that prevents expression of transcribed genes via double-stranded RNA molecules. The discovery of this mechanism won a Nobel prize in 2006 (see previous news) and the therapeutic potential of this process to silence the expres ... ]]></description>
		</item>
			</channel>
</rss>
