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		<title>Articles from the PHG Foundation Newsletter</title>
		<link>http://www.phgfoundation.org/newsletter</link>
		<description>Articles from the PHG Foundation Newsletter</description>
		<copyright>PHG Foundation</copyright>
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			<title>Oversight needed for clinical translation of genome-based tests</title>
			<link>http://www.phgfoundation.org/news/month/03/2012/#story_11528</link>
			<pubDate>Wed, 28 Mar 2012 00:00:00 +0100</pubDate>
			<description><![CDATA[ The Institute of Medicine (IOM) in the US has released a new report calling for an evaluation process to assess whether &amp;lsquo;omics-based&amp;rsquo; tests are valid and ready for clinical use.  &amp;nbsp;  Genome-Based Diagnostics: Clarifying Pathways to Clinical Use is the report from workshops on transla ... ]]></description>
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				<item>
			<title>UK government funding for stratified medicine development</title>
			<link>http://www.phgfoundation.org/news/month/03/2012/#story_11495</link>
			<pubDate>Fri, 23 Mar 2012 00:00:00 +0000</pubDate>
			<description><![CDATA[ New funding of &amp;pound;7.5 million has been made available for stratified medicine development in the UK by the governmental Technology Strategy Board (TSB), to determine whether it can improve current clinical care pathways.  &amp;nbsp;  In partnership with the Department of Health, the TSB is offering  ... ]]></description>
		</item>
				<item>
			<title>Legal ruling blocks personalised medicine patents</title>
			<link>http://www.phgfoundation.org/news/month/03/2012/#story_11488</link>
			<pubDate>Thu, 22 Mar 2012 00:00:00 +0000</pubDate>
			<description><![CDATA[ The US Supreme Court has rejected two patents for a method of monitoring patient blood to determine drug dosage.  &amp;nbsp;  The Prometheus patents were challenged by the Mayo Clinic, which was sued for patent infringement by Prometheus on developing a version of the same test. The first local ruling i ... ]]></description>
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			<title>European pharmacogenetics guidance for drug development</title>
			<link>http://www.phgfoundation.org/news/month/02/2012/#story_11244</link>
			<pubDate>Wed, 15 Feb 2012 00:00:00 +0000</pubDate>
			<description><![CDATA[ The European Medicines Agency (EMA) has issued new guidance on the use of pharmacogenetic methods in evaluating medicinal products.  &amp;nbsp;  Our growing understanding of how genetic factors influence the way in which an individual may respond to medicines is collectively referred to as pharmacogenet ... ]]></description>
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				<item>
			<title>Consultation: genomic influence on pharmacovigilance</title>
			<link>http://www.phgfoundation.org/news/month/02/2012/#story_11172</link>
			<pubDate>Wed, 01 Feb 2012 00:00:00 +0000</pubDate>
			<description><![CDATA[ As we begin to understand the way genes impact on individual responses to prescribed therapies, current guidelines on the evaluation of medicines for clinical use may need updating.&amp;nbsp;  The European Medicines Agency is seeking comments on its concept paper, which sets out a proposal to develop gu ... ]]></description>
		</item>
				<item>
			<title>Drivers and barriers for companion diagnostics</title>
			<link>http://www.phgfoundation.org/news/month/01/2012/#story_10897</link>
			<pubDate>Thu, 05 Jan 2012 00:00:00 +0000</pubDate>
			<description><![CDATA[ The importance of companion diagnostic development and approval as an essential corollary to the development of stratified medicines continues to attract attention.  &amp;nbsp;  In July 2011, US regulator the FDA announced that approval of new forms of stratified medicines was likely to require simultan ... ]]></description>
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				<item>
			<title>Patenting personalised medicine</title>
			<link>http://www.phgfoundation.org/news/month/12/2011/#story_10862</link>
			<pubDate>Fri, 23 Dec 2011 00:00:00 +0000</pubDate>
			<description><![CDATA[ The US Supreme Court has this month been considering whether it is legal for a company to hold a patent covering a biomarker test to determine the most appropriate levels of drug to use for treatment.  &amp;nbsp;  Prometheus Laboratories&amp;rsquo; patent covers a method to determine the most effective dose ... ]]></description>
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				<item>
			<title>Early roadmap for clinical cancer sequencing</title>
			<link>http://www.phgfoundation.org/news/month/12/2011/#story_10673</link>
			<pubDate>Fri, 02 Dec 2011 00:00:00 +0000</pubDate>
			<description><![CDATA[  ]]></description>
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			<title>Ensuring cancer care keeps pace with genomic advances</title>
			<link>http://www.phgfoundation.org/news/month/11/2011/#story_10583</link>
			<pubDate>Mon, 21 Nov 2011 00:00:00 +0000</pubDate>
			<description><![CDATA[ Experts at the Clinical Oncological Society of Australia were warned last week that the country&amp;rsquo;s health system was failing to keep pace with the speed of discovery in genomics.  Speaking at the Annual Scientific Meeting, Dr David Thomas of the Peter MacCallum Cancer Center in Melbourne referr ... ]]></description>
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			<title>World first as genome sequencing offered to entire Faroe islands</title>
			<link>http://www.phgfoundation.org/news/month/09/2011/#story_10106</link>
			<pubDate>Fri, 30 Sep 2011 00:00:00 +0100</pubDate>
			<description><![CDATA[ The Faroe Islands, a self-governing group of islands within the Kingdom of Denmark, are to become the world&amp;rsquo;s first nation offering full genome sequencing to every citizen.  &amp;nbsp;  All 50,000 inhabitants will have the opportunity to participate in the new FarGen project, which will link genom ... ]]></description>
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			<title>Progress in stratified medicine for genetic cancer sub-groups</title>
			<link>http://www.phgfoundation.org/news/month/08/2011/#story_9604</link>
			<pubDate>Sat, 20 Aug 2011 00:00:00 +0100</pubDate>
			<description><![CDATA[ Trials of personalised (or more accurately, stratified) medicines targeted specifically at specific sub-populations of patients will become increasingly common in coming years, especially in cancer. The drug vemurafenib (PLX4032) has just been approved in the US for the treatment of advanced melanom ... ]]></description>
		</item>
				<item>
			<title>Major Chinese study to probe genetics of high cholesterol</title>
			<link>http://www.phgfoundation.org/news/month/08/2011/#story_9569</link>
			<pubDate>Mon, 15 Aug 2011 00:00:00 +0100</pubDate>
			<description><![CDATA[ The researchers say that statins, widely used to reduce cholesterol levels in many countries, are generally much less effective among southern Chinese populations. This study may indeed reveal genetic differences that account for this and could direct the development of new forms of cholesterol-lowe ... ]]></description>
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			<title>Strategic vision for the future of genomic medicine</title>
			<link>http://www.phgfoundation.org/news/month/02/2011/#story_7665</link>
			<pubDate>Mon, 14 Feb 2011 00:00:00 +0000</pubDate>
			<description><![CDATA[ The US National Human Genome Research Institute (NHGRI) has released a strategic plan for the next decade that sets out &amp;lsquo;the path towards an era of genomic medicine&amp;rsquo;.  &amp;nbsp;  Published to coincide with the tenth anniversary of release of the first draft human genome sequence, the paper  ... ]]></description>
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			<title>Experimental melanoma drug shows promise in trials</title>
			<link>http://www.phgfoundation.org/news/month/01/2011/#story_7439</link>
			<pubDate>Sat, 29 Jan 2011 00:00:00 +0000</pubDate>
			<description><![CDATA[ Malignant melanoma is the most aggressive form of skin cancer, and until now has had very few effective treatments after metastasis. Typically, fewer than one in four people survive one year after diagnosis with advanced disease. The new drug is not authorised for general use yet, and so currently r ... ]]></description>
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			<title>Setback for RNA interference therapies</title>
			<link>http://www.phgfoundation.org/news/month/12/2010/#story_6672</link>
			<pubDate>Thu, 02 Dec 2010 00:00:00 +0000</pubDate>
			<description><![CDATA[ The announcement, coming after three years and more than $500 million invested in the research, is part of a corporate restructuring that will involve the cutting of around 6% of Roche&amp;rsquo;s staff worldwide over the next two years. The news has been described as the biggest vote of no confidence i ... ]]></description>
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				<item>
			<title>New personalised cancer care initiative launched</title>
			<link>http://www.phgfoundation.org/news/month/10/2010/#story_6068</link>
			<pubDate>Mon, 25 Oct 2010 00:00:00 +0100</pubDate>
			<description><![CDATA[ CRUK&amp;rsquo;s parallel programme seeks to harness the benefits of genomic medicine to improve cancer diagnosis and management. It will work with selected NHS hospitals and laboratories, and companies Pfizer and Life Technologies, to improve genetic testing services and collect genetic data from patie ... ]]></description>
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				<item>
			<title>Genetic effects on clopidogrel treatment</title>
			<link>http://www.phgfoundation.org/news/month/09/2010/#story_5664</link>
			<pubDate>Mon, 06 Sep 2010 00:00:00 +0100</pubDate>
			<description><![CDATA[ There are potentially enormous clinical benefits of using an individual&amp;rsquo;s genetic sequence to predict how it affects the metabolism or function of a drug (pharmacogenetics), to allow improved dosage and minimise adverse reactions. The body of evidence is already growing with regard to warfarin ... ]]></description>
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			<title>Tumour profiling and stratified medicine</title>
			<link>http://www.phgfoundation.org/news/month/06/2010/#story_5511</link>
			<pubDate>Fri, 04 Jun 2010 00:00:00 +0100</pubDate>
			<description><![CDATA[ Cancer is characterised by massive genomic changes, ranging from single point mutations to major chromosomal rearrangements and duplications (see previous news). As a result, the genome of a cancerous tumour is often very different from other tumours, and indeed from an individual&amp;rsquo;s inherited  ... ]]></description>
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				<item>
			<title>OECD review of human health biotechnologies to 2015</title>
			<link>http://www.phgfoundation.org/news/month/03/2010/#story_5323</link>
			<pubDate>Wed, 31 Mar 2010 00:00:00 +0100</pubDate>
			<description><![CDATA[ The Organisation for Economic Co-operation and Development (OECD) has produced special issue of its Journal, entitled &amp;quot;Agricultural and health biotechnologies: Building blocks of the bioeconomy&amp;rdquo;, which aims to provide evidence-based projections on the development of biotechnologies in agr ... ]]></description>
		</item>
				<item>
			<title>Evidence that pharmacogenetic testing reduces hospitalisations from warfarin</title>
			<link>http://www.phgfoundation.org/news/month/03/2010/#story_5306</link>
			<pubDate>Sat, 20 Mar 2010 00:00:00 +0000</pubDate>
			<description><![CDATA[ The use of genetic testing to predict how different individuals will respond to particular drugs is one of the major areas where genomics is expected to yield enormous clinical benefits across a range of diseases (see previous news). Understanding how an individual&amp;rsquo;s response to medication may ... ]]></description>
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