Common genetic variants in environmentally influenced diseases

18 May 2005

The US National Institute of Environmental Health Sciences (NIEHS) set up the Environmental Genome Project (EGP) in 1997 to investigate the role of common genetic polymorphisms in environmentally induced disease. The project has focused on the discovery and annotation of single nucleotide polymorphisms (SNPs) in candidate environmental disease genes, with the creation of databases that integrate this data with annotated gene models. A total of 213 candidate genes with a possible role in environmental susceptibility to disease were analysed to determine whether functionally significant polymorphisms in the genes affected individuals

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