New reviews and commentaries, 4 April 2006

5 April 2006

Human monogenic disorders - a source of novel drug targets. Brinkman RR (2006) Nat Rev Genet. 7, 249-60. Review article on the prospects for drug discovery using Mendelian genetics (PubMed).

Genetic medicines: treatment strategies for hereditary disorders. O'Connor TP and Crystal RG (2006) Nat Rev Genet. 7, 261-76. Review article on the use of therapies that modify gene expression as treatments for monogenic disorders, including barriers to clinical application (PubMed).

Mendelian disorders deserve more attention. Antonarakis SE and Beckmann JS (2006) Nat Rev Genet. 7, 277-82. Personal perspective on the danger of overlooking Mendelian disorders in favour of multifactorial diseases, since research into the former is likely to be of value in understanding the latter (PubMed).

Genetic susceptibility to infectious disease: lessons from mouse models of leishmaniasis. Lipoldova M and Demant P (2006) Nat Rev Genet. 7, 294-305. Review (PubMed).

Genetics of Parkinson disease: paradigm shifts and future prospects. Farrer MJ (2006) Nat Rev Genet. 7, 306-18. Review article detailing how genetic research is providing improved diagnosis and novel therapeutic strategies for Parkinsin disease (PubMed).

From teratocarcinomas to embryonic stem cells and beyond: a history of embryonic stem cell research. Solter D (2006) Nat Rev Genet. 7, 319-27. Timeline looking at the history of stem cell research in the light of its increasingly prominent media profile (PubMed).

NPHS2 gene, nephritic syndrome and focal segmental glomerulosclerosis: a HuGE review. Franceschini N (2006) Genet Med. 8, 63-75. Review on nephrotic syndrome, a form of kidney disease, and its association with NPHS2 gene variants (PubMed).

Stops along the RAS pathway in human genetic disease. Bentires-Alj M, Kontaridis MI and Neel BG (2006) Nat Med.12, 283-285. News and Views piece on how mutations in the RAS-MAPK cellular pathway provide a common underlying mechanism for a range of related human 'neuro-cardio-facial-cutaneous' (NCFC) syndromes (PubMed).

Roots and stems: stem cells in cancer. Polyak K, Hahn WC (2006) Nat Med.12, 296-300. Perspective on putative cancer stem cells, populations of self-renewing cells with tumourigenic potential that may be present in tumours (PubMed).

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