New reviews and commentaries, 6 February 2007

6 February 2007

Genetics of ischaemic stroke. Dichgans M (2007) Lancet Neurol 6(2):149-61 Review (PubMed).

The genetics of the polycystic ovary syndrome. Urbanek M (2007) Nat Clin Pract Endocrinol Metab 3(2):103-11 Review (PubMed)

The evolution of gene regulation by transcription factors and microRNAs. Chen K and Rajewsky N (2007) Nat Rev Genet. 8(2):93-103. Review (PubMed).

Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions. Lanctôt C et al. (2007)Nat Rev Genet. 8(2): 104-115. Review on the role of genomic repositioning movements in the control of gene expression (PubMed).

The evolution of sex: empirical insights into the roles of epistasis and drift. de Visser JA and Elena SF (2007) Nat Rev Genet. 8(2): 139-149. Review on new modelsinvolving genetic factors for theevolution of sex as a reproductive strategy (PubMed).

Educating health-care professionals about genetics and genomics. Guttmacher AE, Porteous ME and McInerney JD (2007) Nat Rev Genet. 8(2): 151-157. ‘Science and society’ perspective article on the importance of genetic and genomic awareness among primary health-care providers and efforts to achieve it (PubMed).

Advocacy groups as research organizations: the PXE International example. Terry SF et al. (2007) Nat Rev Genet. 8(2): 157-164. ‘Science and society’ perspective article on the role of patient advocacy groups as coordinators of translational research in genetic diseases (PubMed).

Overview of the pharmacogenomics of cigarette smoking. Ho MK and Tyndale RF (2007) Pharmacogenomics J [Epub ahead of print]. Review on current knowledge of genetic factors involved in smoking behaviours and how genetic variations may affect therapeutic outcomes for smoking cessation drugs (PubMed).

Pharmacogenomics and nutrigenomics: synergies and differences.Ghosh D, Skinner MA and Laing WA (2007) Eur J Clin Nutr [Epub ahead of print]. Review on the potential for increasing alignment of pharmacogenomics and nutrigenomics in the years ahead (PubMed).

Multiple mutations responsible for frequent genetic diseases in isolated populations. Zlotogora J (2007) Eur J Hum Genet [Epub ahead of print]. Review looking at possible explanations for autosomal recessive diseases that occur at high frequencies in isolated populations (PubMed).

Cancer risks among BRCA1 and BRCA2 mutation carriers. Levy-Lahad E and Friedman E (2007) Br J Cancer 96(1):11-5 Minireview of individualised risk prediction including genetic factors for breast cancer (PubMed).

The ethical implications of stratifying by race in pharmacogenomics. Lee SS (2007) Clin Pharmacol Ther 81(1):122-5. Article on the necessity to determine an accurate categorization of individuals and populations in order to link genetic variants with drug responses appropriately for applications in personalized medicine (PubMed).

The PharmGKB: integration, aggregation, and annotation of pharmacogenomic data and knowledge. Hodge AE, Altman RB and Klein TE (2007) Clin Pharmacol Ther81(1):21-4. Article on the Pharmacogenetics and Pharmacogenomics Knowledge Base (PubMed).

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