Selected new reviews and commentaries, 1 June 2010

27 May 2010

Is modern genetics a blind alley? Yes.
 
Is modern genetics a blind alley? No.
 
 
Ten Years On — The Human Genome and Medicine
 
Uncovering the roles of rare variants in common disease through whole-genome sequencing.
 
Challenges in the clinical application of whole-genome sequencing.
 
Missing heritability and strategies for finding the underlying causes of complex disease.
 
Genomics goes beyond DNA sequence.
 
Gene regulation: Breaking the second genetic code.
 
Transcription: Enhancers make non-coding RNA.
 
Informed Consent in Genomics and Genetic Research.
 
Research ethics. Beyond access vs. protection in trials of innovative therapies.
 
Reaching the limits of genome-wide significance in Alzheimer disease: back to the environment.
 
Chromosome 9p21 and coronary artery disease.
 
Mendelian randomisation, triglycerides, and CHD.
 
Neuroscience. Epigenetics and cognitive aging.
 
Susceptibility pathways in Fanconi's anemia and breast cancer.

D'Andrea AD. N Engl J Med. 2010 May 20;362(20):1909-19.  

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