3 January 2008
Human variome microattribution reviews. (2008)Nat Genet. 40(1):1. Editorial setting out policy for commissioning reviews on variation at selected genomic loci, as an incentive to stimulate ‘high-quality community annotation of the human genome’ (PubMed).
Copy-number analysis goes more than skin deep. McCarroll SA (2008) Nat Genet. 40(1):5-6. News and views article looking at new research into copy-number polymorphisms in psoriasis and how it may influence future attempts to measure such variants (PubMed).
Genomic rearrangements in the spotlight. Osborne LR (2008) Nat Genet. 40(1):6-7. News and views article on new evidence that suggests genomic rearrangements such as microdeletions are currently significantly underdiagnosed (PubMed).
BRCA1- sowing the seeds crooked in the furrow. Foulkes WD (2008) Nat Genet. 40(1):8-9. News and views article on a study showing that microdeletions in the PTEN gene are a common signature of DNA repair deficiency in breast tumours, especially in BRCA1 mutation carriers (PubMed).
The emerging landscape of breast cancer susceptibility. Stratton MR, Rahman N (2008) Nat Genet. 40(1):17-22. Perspectives piece on current understanding of genetic susceptibility to breast cancer and how this may provide insight into other common diseases (PubMed).
Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges. Wilke RA et al. (2007) Nat Rev Drug Discov. 6(11):904-16. Review looking at three specific types of adverse drug reaction: liver damage, myotoxicity and the cardiac conditions long QT and torsades de pointes (PubMed).
Human Genetics: The Hidden Text of Genome-wide Associations. Gibson G, Goldstein DB (2007) Curr Biol. 17(21):R929-32. Review looking at the challenges in translating emerging evidence of genetic associations with complex diseases into public health outcomes, and integrating this information with broader biological understanding of disease processes (PubMed).
Rules of engagement. Taylor PL (2007) Nature 450(7167):163-4. Commentary arguing that more public engagement over scientific issues is necessary to maintain public confidence (PubMed).
A timely harvest. Joly PB, Rip A (2007) Nature 450(7167):174. Essay proposing that public opinion should be sought earlier in the process of science and policy development, when there is still room for their opinions to influence strategy (PubMed).
Public health. Biobanks in developing countries: needs and feasibility. Sgaier SK et al. (2007) Science 318(5853):1074-5. Policy forum piece looking at the scope for developing biobanks in developing countries and prospects for international collaboration between biobank projects (PubMed).
New links to the pathogenesis of Crohn disease provided by genome-wide association scans. Mathew CG (2008)Nat Rev Genet. 9(1):9-14. Summary of recent findings, also exploring the possibility that GWAs may provide new insight into causal genetic variants and disease (PubMed).
Nucleosome destabilization in the epigenetic regulation of gene expression. Henikoff S (2008) Nat Rev Genet. 9(1):15-26. Review (PubMed).
Coupling and coordination in gene expression processes: a systems biology view. Komili S, Silver PA (2008)Nat Rev Genet. 9(1):38-48. Review of functional interactions involved in the regulation of gene expression (PubMed).
Steady progress and recent breakthroughs in the accuracy of automated genome annotation. Brent MR (2008) Nat Rev Genet. 9(1):62-73. Review of progress in genome annotation (PubMed).
Accommodating dissent. Leach M (2007) Nature 450(7169):483. Science and politics essay arguing that scientists and policy-makers must take public opinion more seriously in the development of health programmes; failure to properly engage with issues (even those that are cultural or emotional in origin) risks wasted investment in public health through public mistrust (PubMed).
The two faces of miRNA. Buchan JR, Parker R (2007) Science 318(5858):1877-8. Perspectives piece on the capacity of miRNAs to stimulate or block translation of target mRNAs, accompanying new research (PubMed).
Is therapeutic cloning dead? Cibelli J (2007) Science 318(5858):1879-80. Perspectives piece looking at whether human therapeutic cloning to produce sources of stem cells will be necessary in the light of recent developments in inducing pluripotency in non-embryonic stem cells (PubMed).
Implementation science. Madon T, Hofman KJ, Kupfer L, Glass RI (2007) Science 318(5857):1728-9. Policy forum article looking at the difficulties in translating scientific advances into health benefits, especially in poorer countries, and proposing a framework for implementation research (PubMed).
Cancer diagnostics: One-stop shop. Uhr JW (2007) Nature 450(7173):1168-9. News and views piece on a new ‘lab-on-a-chip’ device that can separate and quantify circulating tumour cells (PubMed)
Molecular biology: genome under surveillance. Arndt KM (2007) Nature 450(7172):959-60. News and Views piece on how a yeast protein regulates gene expression across the genome via a chromatin-based mechanism (PubMed).
Proteins to proteomes. Chouard T, Finkelstein J (2007) Nature 450(7172):963. Editorial introducing special Insight feature section onproteomics and systems biology (PubMed).
Cystic fibrosis. Davies JC, Alton EW, Bush A (2007) BMJ 335(7632):1255-9. Clinical review (PubMed).
The ethical regulation of science. Warnock M (2007) Nature 450(7170):615. Science and policy essay on the inherent problems in effective regulation of controversial research (such as that involving human embryos) which is subject to public rather than private morality (PubMed).
The influence of genetic variation on gene expression. Williams RB, Chan EK, Cowley MJ, Little PF (2007) Genome Res.17(12):1707-16. Review concluding that, although the influence of genetic variation on gene-expression levels is increasingly understood, there is a long way to go in understanding how this translates into phenotypic and evolutionary outcomes (PubMed).
Genetics of late-onset Alzheimer's disease: progress and prospect. Li Y, Grupe A (2007) Pharmacogenomics 8(12):1747-55. Review suggesting that since genetic susceptibility factors (with the exception of APOE4) for late-onset Alzheimer's disease are likely to have only weak effects, greater research collaboration will be needed to identify and exploit them for diagnosis, prognosis and therapy (PubMed).
Hereditary colorectal cancer syndromes: molecular genetics, genetic counseling, diagnosis and management. Lynch HT, Lynch JF, Lynch PM, Attard T (2007) Fam Cancer. Nov 13; [Epub ahead of print]. Review, including the recommendation that where there is a significant family history but no mutation is identified, surveillance and management strategies should be implemented anyway (PubMed).
Genetic profiling and tailored therapy in asthma: Are we there yet? Lugogo NL, Ginsburg GS, Que LG (2007)Curr Opin Mol Ther. 9(6):528-37. Reviewon the pharmacogenomics of asthma therapeutics and prospects for genotyping as a tool to guide treatment (PubMed).
The impact of pharmacogenetics on the development and use of antipsychotic drugs. Reynolds GP (2007)Drug Discov Today. 212(21-22):953-9. Review on the prospects for pharmacogenetic testing to guide antipsychotic drug use (PubMed)
Constitutional polymorphisms of prostate cancer: prognostic and diagnostic implications. Hahn NM, Kelley MR, Klaunig JE, Koch MO, Li L, Sweeney CJ (2007) Future Oncol. 3(6):665-682. Review on the potential of microarray SNP analysis to identify patients at high risk of developing aggressive lethal forms of prostate cancer (PubMed).
Can genomics help heal the schism between medicine and public health? Muin J. Khoury (presentation) and Genomic medicine and health disparities. Charles Rotimi (presentation). Online seminars provided by the US CDC National Office of Public Health Genomics and National Center for Chronic Disease Prevention and Health Promotion