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Polygenic scores for cancerReportAn overview of what is known about polygenic scores and what they could mean for cancer prediction, prevention and management. A short report for health policy makers and other stakeholders.
Evaluation of polygenic risk score applicationsReportHow current evidence is inadequate to determine clinical validity or utility of a polygenic score product in relation to its intended purpose and what is needed to resolve the gaps
Implementing polygenic scores for cardiovascular disease into NHS Health ChecksReportWe evaluate the NHS Health Check programme as a possible exemplar for the introduction of the routine use of polygenic score analysis.
Polygenic scores and clinical utilityReportThis report brings together key concepts around clinical utility. Using our expertise on genetic test evaluation and regulation we consider how to better assess the potential utility of polygenic scores in healthcare.
Personalising breast cancer prevention – bridging the gap between research and policyReportA comprehensive overview of the rapidly advancing science underpinning breast cancer prevention
Polygenic scores and riskResearchPolygenic scores combine information from multiple genetic variants into a single score that can be used to examine risk. Recent advances in this field have reignited interest in using genetic information in personalised prevention approaches for common conditions such as cancer and heart disease.
Polygenic scores, risk and cardiovascular diseaseReportPublished in 2019, this reports examines the evidence and readiness for clinical implementation of polygenic scores from the perspective of cardiovascular disease prevention.
PHG commentary: ACMG statement on clinical application of polygenic risk scoresBlogThe ACMG has provided a useful and timely reminder, and much needed clarity, that there is some way to go before polygenic scores can be used routinely in healthcare.